Mutational landscape of high-grade B-cell lymphoma with < em > MYC < /em > -, < em > BCL2 < /em > and/or < em > BCL6 < /em > rearrangements characterized by whole-exome sequencing

This study elucidates a recurrent pattern of mutational events driving FL into MYC-driven BCL2 rearranged HGBL, unveiling the mutational pathogenesis of this provisional entity. Through this refinement of the molecular taxonomy for aggressive, germinal-center derived B-cell lymphomas, this calls into question the current WHO-classification system, especially regarding the status of MYC/BCL6 rearranged HGBL.PMID:34788985 | DOI:10.3324/haematol.2021.279631

Source: Haematologica - November 18, 2021 Category: Hematology Authors: Axel K ünstner Hanno M Witte J örg Riedl Veronica Bernard Stephanie St ölting Hartmut Merz Vito Olschewski Wolfgang Peter Julius Ketzer Yannik Busch Peter Trojok Nikolas von Bubnoff Hauke Busch Alfred C Feller Niklas Gebauer Source Type: research