Alzheimer's: Exercise may reduce brain inflammation, helping to protect us from the disease

The study's researchers looked at 167 men and women who participated in the Rush Memory and Aging Project. This is a long-term project at Rush University in Chicago which seeks to identify factors that contribute to brain health in older people.
Source: The Economic Times - Category: Consumer Health News Source Type: news

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CONCLUSIONS: Boosting KYNA levels, through interference with the KP enzymes or through application of prodrugs/analogs with high bioavailability and potency, is a promising clinical approach. The use of KYNA, alone or in combination with other compounds precisely influencing specific populations of neurons, is awaiting to become a significant therapy for neurodegenerative disorders.PMID:34862742 | DOI:10.1111/cns.13768
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
Conclusion: Medical students lack significant knowledge and training about dementia. Patient contact and practical training for basic assessment and care of dementia needs to be incorporated in the current academic curriculum. Dedicated sensitization sessions on dementia care can help improve the gap. Practical exposure to management of patients with dementia would be required to enhance the comfort level and attitude of students towards dementia.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Photo credit Berhard Grossgastieger The only certainty, when diagnosed with Alzheimer's disease, is that a senior’s condition will progressively worsen. The national Alzheimer’s Association has developed a very useful staging system to use as a frame of reference when coping with AD. Alzheimer's disease constantly keeps doctors, family members, and caregivers on their toes. It is instinctive for humans to want a roadmap or some sort of guide to help get us through a journey or a difficult situation. We strive to know what lies ahead to help ensure that we are adequately prepared. Following a serious medica...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Condition:   Alzheimer Disease Interventions:   Drug: Nilotinib BE 84mg;   Drug: Nilotinib BE 112 mg;   Drug: Placebo Sponsors:   KeifeRx, LLC;   Worldwide Clinical Trials;   Life Molecular Imaging GmbH;   Sun Pharmaceuticals Industries Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CMS has embarked on a national coverage determination process, in which it's examining the clinical safety and benefit profile of Aduhelm and other anti beta amyloid monoclonal antibodies in Alzheimer ’s patients. As CMS decides whether to pay for Aduhelm its future success is uncertain.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation business pharma & Source Type: news
CONCLUSION: Minocycline mitigates Alzheimer's-like pathology via limiting the activation of Cdk5/p25 signaling pathway and improves cognitive deficits.PMID:34856907 | DOI:10.2174/1570159X19666211202124925
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Curr Neuropharmacol. 2021 Dec 2. doi: 10.2174/1570159X19666211202124239. Online ahead of print.ABSTRACTRecent findings have improved our understanding of the multifactorial nature of AD. While in early, asymptomatic stages of AD, increased amyloid-β synthesis and tau hyperphosphorylation play a key role, in the later stages of the disease, numerous dysfunctions of homeostatic mechanisms in neurons, glial cells and cerebrovascular endothelium determine the rate of progression of clinical symptoms. The main driving forces of advanced neurodegeneration include: increased inflammatory reactions in neurons and glial cells,...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Conclusion: The present study highlights potential benefits of community-based arts activities in enabling caregiving to be a more positive experience for care partners.Supplemental data for this article is available online at http://dx.doi.org/10.1080/13607863.2021.2008306'I kept blaming myself for not spending enough time with him. Communication with him is different now. Watching him on the stage, he is happy and with a purpose'. (Gary, male).PMID:34856835 | DOI:10.1080/13607863.2021.2008306
Source: Aging and Mental Health - Category: Geriatrics Authors: Source Type: research
EMBO Mol Med. 2021 Dec 3:e14408. doi: 10.15252/emmm.202114408. Online ahead of print.ABSTRACTNeurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public health challenge. As these diseases are difficult to diagnose clinically, biomarkers of underlying pathophysiology are playing an ever-increasing role in research, clinical trials, and in the clinical work-up of patients. Though cerebrospinal fluid (CSF) and positron emission tomography (PET)-based measures are available, their use is not widespread due to limitations, including high costs and perceived invasiveness. As a result of rapid advanc...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Exp Mol Med. 2021 Dec 2. doi: 10.1038/s12276-021-00703-x. Online ahead of print.ABSTRACTThe gut is connected to the CNS by immunological mediators, lymphocytes, neurotransmitters, microbes and microbial metabolites. A mounting body of evidence indicates that the microbiome exerts significant effects on immune cells and CNS cells. These effects frequently result in the suppression or exacerbation of inflammatory responses, the latter of which can lead to severe tissue damage, altered synapse formation and disrupted maintenance of the CNS. Herein, we review recent progress in research on the microbial regulation of CNS disea...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
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