Peritoneal Modulators of Endometriosis-Associated Ovarian Cancer

Ovarian cancer is the 4th largest cause of cancer death in women. Approximately 10–15% of women of childbearing age suffer from endometriosis. Endometriosis is defined by the growth and presence of endometrial tissue (lesions) outside of the uterus. The women with endometriosis also have an increased presence of peritoneal fluid (PF) that comprises of inflammatory cells, growth factors, cytokines/chemokines, etc. Epidemiological studies have shown that>3% of women with endometriosis develop ovarian cancer (low-grade serous or endometrioid types). Our hypothesis is that the PF from women with endometriosis induces transformative changes in the ovarian cells, leading to ovarian cancer development. PF from women with and without endometriosis was collected after IRB approval and patient consent. IOSE (human normal ovarian epithelial cells) and TOV-21G cells (human ovarian clear cell carcinoma cell line) were treated with various volumes of PF (no endometriosis or endometriosis) for 48 or 96 h and proliferation measured. Expression levels of epigenetic regulators and FoxP3, an inflammatory tumor suppressor, were determined. A Human Cancer Inflammation and Immunity Crosstalk RT2 Profiler PCR array was used to measure changes in cancer related genes in treated cells. Results showed increased growth of TOV-21G cells treated with PF from women with endometriosis versus without endometriosis and compared to IOSE cells. Endo PF treatment induced EZH2, H3K27me3, and FoxP3. The ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Researchers derived and validated a proprietary screening test to detect pancreatic cancer in people with new-onset diabetes. The test uses an epigenetic analysis of a 20 mL blood specimen.First Look
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Diabetes & Endocrinology News Source Type: news
Cancer Gene Therapy, Published online: 14 January 2022; doi:10.1038/s41417-021-00413-6Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
International Journal of Obesity, Published online: 14 January 2022; doi:10.1038/s41366-021-01045-4Vitamin D deficiency: a potential risk factor for cancer in obesity?
Source: International Journal of Obesity - Category: Eating Disorders & Weight Management Authors: Source Type: research
Risk for both all - cause and cancer - specific death increased for cancer survivors with combination of prolonged sitting and inactivity
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Internal Medicine, Oncology, Journal, Source Type: news
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT04079K, PerspectiveJo ão Franco Machado, Tânia S. Morais Chemotherapeutic metallodrugs such as cisplatin and its derivatives are among the most widely applied anticancer treatments worldwide. Nonetheless their clinical success, patients suffer from severe adverse effects while subjected to... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC05148B, CommunicationMeng Ye, Wan-Qiong Huang, Zi-Xin Li, Chuan-Xian Wang, Tao Liu, YunZhou Chen, Catherine Hong-Huan Hor, Wai-Lun Man, Wen-Xiu Ni A new octahedral osmium(VI) nitrido complex with no labile ligandtrans to the nitride was reported. This complex causes liver cancer cell mitochondrial damage, and induces oncosis and apoptosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
"Even in early-stage disease, ovarian cancer is not necessarily a silent disease."Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Ob/Gyn & Women ' s Health News Source Type: news
Cancer-focused precision medicine startup Scorpion Therapeutics, founded by serial entrepreneur Gary Glick and now headed up by GlaxoSmithKline plc veteran Axel Hoos, has made its next major move: signing a collaboration agreement worth up to $1.6 billion with the pharmaceutical giant AstraZeneca plc.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
The impressive data on how HPV vaccination has cut cervical cancer rates tells only part of the story of how many other lives could be transformed.WebMD Health News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Nursing, Oncology, Pharmacy, Research, News, Source Type: news
More News: Cancer | Cancer & Oncology | Cancer of the Uterus | Carcinoma | Child Development | Clear Cell Carcinoma | Endometrial Cancer | Endometriosis | Epidemiology | Epithelial Cancer | Genetics | Ovarian Cancer | Ovaries | Serous Carcinoma | Study | Women