It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

by Ana Luisa Carvalho, Dominique Fernandes

Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to medi ate synaptic scaling.

This Primer explores the implications of a new study in PLOS Biology which reveals how homeostatic synaptic plasticity requires coordinated and inter-dependent protein synthesis and degradation, as well as remodeling of the miRNA-induced silencing complex.

Source: PLoS Biology: Archived Table of Contents - November 24, 2021 Category: Biology Authors: Ana Luisa Carvalho Source Type: research