Lower uric acid level may be associated with hemorrhagic transformation after intravenous thrombolysis

AbstractBackgroundPrevious studies have shown that uric acid (UA) is a powerful water-soluble antioxidant and free radical scavenger for humans. However, the relationship between serum uric acid (SUA) and hemorrhagic transformation (HT) is still controversial. To address this challenge, we aimed to explore the association between serum UA and HT in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT).MethodsA retrospective analysis was conducted in patients with anterior circulation AIS who underwent IVT at Affiliated Hospital of Qingdao University from 2016 to 2021. HT was evaluated by CT or MRI within 7  days after admission. Baseline demographic, clinical, and laboratory data were compared between the HT and non-HT groups, and between different types of HT groups which were documented according to the European Cooperative Acute Stroke Study III Classification (ECASS III).ResultsA total of 727 AIS patients were enrolled, including 112 patients who experienced HT (HT group) and 615 patients who did not experience HT (non-HT group). Patients with HT had significantly lower UA levels compared to those without HT (253.65  ± 97.75 vs 315.97 ± 96.42,p 
Source: Neurological Sciences - Category: Neurology Source Type: research

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CONCLUSIONS: Our study is the first to show the prospective association between dietary Mn intake and reduced risk of mortality from CVD in the Japanese population.PMID:35082202 | DOI:10.5551/jat.63195
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
Lipoxins (LXs) are generated from arachidonic acid and are involved in the resolution of inflammation and confer protection in a variety of pathological processes. In the nervous system, LXs exert an array of protective effects against neurological diseases, including ischemic or hemorrhagic stroke, neonatal hypoxia-ischemia encephalopathy, brain and spinal cord injury, Alzheimer’s disease, multiple sclerosis, and neuropathic pain. Lipoxin administration is a potential therapeutic strategy in neurological diseases due to its notable efficiency and unique superiority regarding safety. Here, we provide an overview of L...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Stroke, Ischemic;   Stroke Hemorrhagic;   Spasticity, Muscle;   Spastic Gait Intervention:   Other: Radial extracorporeal shock wave therapy and conventional physical therapy Sponsor:   Carol Davila University of Medicine and Pharmacy Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Front Neurosci. 2022 Jan 5;15:789852. doi: 10.3389/fnins.2021.789852. eCollection 2021.ABSTRACTObjective: Whether the cerebral vascular variations play an important role in the progression of intracranial atherosclerosis is yet largely unclear. We aimed to investigate the relationship between the magnitude of the vertebrobasilar junction (VBJ) angle and the imaging features of vertebrobasilar artery atherosclerosis. Methods: Adult patients with acute ischemic stroke or transient ischemic attack undergoing a 3.0-tesla vessel wall magnetic resonance imaging (VW-MRI) scanning were consecutively included. Imaging features of v...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Lipids Health Dis. 2022 Jan 22;21(1):15. doi: 10.1186/s12944-021-01620-8.ABSTRACTBACKGROUND: Bile acids (BAs) not only play an important role in lipid metabolism and atherosclerosis but also have antiapoptotic and neuroprotective effects. However, few studies have focused on the relationship of the total bile acid (TBA) levels with the severity and prognosis of acute ischemic stroke (AIS).OBJECTIVES: The aim of this study was to investigate the potential associations of the fasting serum TBA levels on admission with the stroke severity, in-hospital complication incidence and 3 -month all-cause mortality in patients with AI...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Cell Mol Neurobiol. 2022 Jan 23. doi: 10.1007/s10571-021-01183-3. Online ahead of print.ABSTRACTAs the second-leading cause of death, stroke faces several challenges in terms of treatment because of the limited therapeutic interventions available. Previous studies primarily focused on metabolic and blood flow properties as a target for treating stroke, including recombinant tissue plasminogen activator and mechanical thrombectomy, which are the only USFDA approved therapies. These interventions have the limitation of a narrow therapeutic time window, the possibility of hemorrhagic complications, and the expertise required ...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Source Type: research
Stud Health Technol Inform. 2022 Jan 14;289:439-442. doi: 10.3233/SHTI210952.ABSTRACTThe aim of this study was to calculate the average operational cost per sub-type of stroke patient and to investigate cost drivers (e.g. ALoS, NIHSS score, age) correlated to cost.METHODS: Direct medical costs (diagnostic imaging and clinical laboratory exams, overheads/bed cost, pharmaceuticals, ringers and other non-durables and inpatient rehabilitation) per patient were calculated from the providers' (hospitals') perspective. Resource use data derived from the "SUN4P" web-based registry and unit costs were retrieved from publi...
Source: Studies in Health Technology and Informatics - Category: Information Technology Authors: Source Type: research
CONCLUSIONS: These data are in accordance with current evidence and should be thoroughly assessed in order to ensure optimal therapeutic management of stroke patients.PMID:35062158 | DOI:10.3233/SHTI210925
Source: Studies in Health Technology and Informatics - Category: Information Technology Authors: Source Type: research
Stud Health Technol Inform. 2022 Jan 14;289:439-442. doi: 10.3233/SHTI210952.ABSTRACTThe aim of this study was to calculate the average operational cost per sub-type of stroke patient and to investigate cost drivers (e.g. ALoS, NIHSS score, age) correlated to cost.METHODS: Direct medical costs (diagnostic imaging and clinical laboratory exams, overheads/bed cost, pharmaceuticals, ringers and other non-durables and inpatient rehabilitation) per patient were calculated from the providers' (hospitals') perspective. Resource use data derived from the "SUN4P" web-based registry and unit costs were retrieved from publi...
Source: Studies in Health Technology and Informatics - Category: Information Technology Authors: Source Type: research
CONCLUSIONS: These data are in accordance with current evidence and should be thoroughly assessed in order to ensure optimal therapeutic management of stroke patients.PMID:35062158 | DOI:10.3233/SHTI210925
Source: Studies in Health Technology and Informatics - Category: Information Technology Authors: Source Type: research
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