Thyroid lobectomy for low-risk thyroid cancers

Ann R Coll Surg Engl. 2021 Nov 23. doi: 10.1308/rcsann.2021.0058. Online ahead of print.ABSTRACTBACKGROUND: The 2016 American Thyroid Association (ATA) guidelines proposed thyroid lobectomy for low-risk differentiated thyroid cancer (DTC); however, this approach is yet to be widely adopted. The aim of the study was to review our practice over three years following the publication of these guidelines identifying patients who underwent lobectomy-only for low-risk DTC in two regional units in the same multidisciplinary team (MDT).METHOD: A retrospective review of patients who were operated between January 2016 and December 2018 was carried out.RESULTS: In total, 288 patients undergoing thyroid surgery were included. The preoperative distribution of cytology was: Thy 1 or 2 in 46, THY3a in 57, THY3f in 154, THY4 in 18 and THY5 in 13 patients. Median size of nodules was 26mm (range 1-70mm). DTC was diagnosed in 95 patients (33%). Overall, 39% (n = 37) of patients underwent completion thyroidectomy according to ATA recommendations on size or adverse histological features. The only variable associated with likelihood of completion was tumour size (p
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Source Type: research

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Condition:   Thyroid Carcinoma Intervention:   Procedure: Thyroidectomy Sponsor:   University of Cagliari Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Pregnancy in differentiated thyroid cancer survivors should be managed and monitored with caution, especially when cancer recurrence is noticed. Further studies are recommended to investigate these previously unreported gene mutations associated with thyroid cancer.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
IntroductionWith the growing esthetic requirements, endoscopic thyroidectomy develops rapidly and is widely accepted by practitioners and patients to avoid the neck scar caused by open thyroidectomy. Although ambulatory open thyroidectomy is adopted by multiple medical centers, the safety and potential of ambulatory endoscopic thyroidectomy via a chest-breast approach (ETCBA) is poorly investigated.Material and MethodsPatients with thyroid nodules who received conventional or ambulatory ETCBA at Xiangya hospital, Central South University from January 2017 to June 2020 were retrospectively included. The incidence of postope...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
CONCLUSION: The degree of cost savings and improved patient utility of de-escalated NIFTP management compared to traditional management was estimated to be $3,883.05 and 0.03 QALYs per patient. We demonstrated that these findings persisted in sensitivity analysis to account for variability in recurrence rate, surveillance approaches, and other model inputs. These findings allow for greater understanding of the economic and quality-of-life impact of NIFTP re-classification.PMID:34915744 | DOI:10.1089/thy.2021.0486
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Source Type: research
Mol Clin Oncol. 2022 Jan;16(1):13. doi: 10.3892/mco.2021.2450. Epub 2021 Nov 21.ABSTRACTMultiple endocrine neoplasia (MEN) with medullary thyroid carcinoma (MTC) is associated with rearranged during transfection (RET) mutations. The authors encountered four cases of MTC-related MEN type 2B (MEN2B) with RET codon M918T mutation in one family. Case 1 included a 19 year-old male diagnosed with MTC with lung metastases. Genetic testing revealed an RET codon M918T mutation, which indicated MEN2B. The patient responded partially to vandetanib and the disease has shown no progression in 25 months. Case 2 involved the mother of th...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Ear Nose Throat J. 2021 Dec 6:1455613211060167. doi: 10.1177/01455613211060167. Online ahead of print.ABSTRACTCarcinoma showing thymus-like differentiation (CASTLE) is a rare malignant tumor that accounts for 0.1%-0.15% of all thyroid cancers. More than half of the patients have tumor extension to adjacent organs, including the recurrent laryngeal nerve, trachea, and esophagus. The diagnosis of CASTLE is based on histology and immunohistochemistry. A 58-year-old female patient complained of hoarseness for one and half years. Right side vocal cord palsy was diagnosed by fiberscopy. Thyroid sonography revealed right thyroid ...
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Source Type: research
Conclusions: Compared with conventional OT, ET is a feasible, practical, and safe procedure with excellent cosmetic benefits.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
This cohort study determines adoption rates of 2 recent strategies developed to limit overtreatment of low-risk thyroid cancers: a new classification, noninvasive follicular thyroid neoplasm with papillarylike nuclear features, and hemithyroidectomy for selected papillary thyroid carcinomas up to 4 cm in size.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
Neuropsychiatric symptoms, especially acute psychosis (often referred to as myxedema madness or psychosis), are rare but possible clinical presentations of patients with hypothyroidism. A 42-year-old woman with papillary thyroid carcinoma and recent total thyroidectomy had developed flat affect, paranoid delusion, and visual and auditory hallucination during inpatient admission for elective radioactive iodine treatment. On admission, her history and physical exam did not reveal symptoms and signs of significant hypothyroidism. Other medical causes of acute psychosis were excluded, and the patient was immediately treated wi...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionSince incidence of CNMTC is not negligible, MTC should not be ruled out in the diagnostic phase even if serum calcitonin is negative in preoperative examination. We presented 19 cases of CNMTC whose prognosis in general were favorable. Markers of serum and immunohistochemical samples other than calcitonin should be actively examined.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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