PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.

In conclusion, the lack of PI3Kγ revealed a deleterious effect in an animal model of convulsions induced by pilocarpine, suggesting that this enzyme may play a protective role in seizures and pathological outcomes associated with this condition.
PMID: 25749189 [PubMed - as supplied by publisher]

Source: Experimental Neurology - March 4, 2015 Category: Neurology Authors: de Assis Lima IV, Campos AC, Miranda AS, Marciano ÉL, Amaral-Martins F, Vago JP, de Melo RP, de Sousa LP, Vieira LB, Teixeira MM, Fiebich BL, Moraes MF, Teixeira AL, de Oliveira AC Tags: Exp Neurol Source Type: research