Allopurinol attenuates postoperative pain and modulates the purinergic system in patients undergoing abdominal hysterectomy: a randomized controlled trial

ConclusionThis study showed a short-term benefit of the use of allopurinol as a preanesthetic medication since it was related to a reduction on pain scores 2  h after surgery. The purinergic system is a potential target for new analgesic drugs. New studies investigating more selective purine derivatives in the management of pain should be performed.Trial number registrationBrazilian Registry of Clinical Trials —ReBEC #RBR-9pw58p.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research