Synthesis and antimicrobial activity of ursolic acid ester derivatives

In this study, sixteen esters ( 1 - 16 ) were synthesized from ursolic acid using DIC/DMAP and characterized by infrared and nuclear magnetic resonance ( 1 H- and 13 C-NMR) spectrometry. All ursolic acid esters were evaluated against the bacteria Bacillus cereus , Staphylococcus aureus , Escherichia coli , Salmonella typhimurium , and the yeast Candida albicans . Six compounds are herein described for the first time ( 3 , 9 , 11 , 13 , 14 and 16 ) with reaction yields up to 91.6%. Compounds 11 (3 β- (3,4-dimethoxybenzoyl) ursolic acid) and 15 (3 β -nicotinoyl ursolic acid) displayed promising antifungal activity, with inhibition of C. albicans growth of 93.1 and 95.9%, respectively.PMID:34793623 | DOI:10.1002/cbdv.202100566
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research

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Bioorg Chem. 2021 Nov 22:105507. doi: 10.1016/j.bioorg.2021.105507. Online ahead of print.ABSTRACTPreparation and comprehensive characterization of three Schiff base ligands; with trimethoxy substitution (1E,1'E)-N,N'-(naphthalene-1,5-diyl)bis(1-(3,4,5-trimethoxyphenyl)methanimine, 1, with ortho-hydroxy substitution 6,6'-((1E,1'E)-(naphthalene-1,5-diylbis(azaneylylidene))bis(methaneylylidene))bis(2-methoxyphenol), 2 and 3,4-bis(((E)-2-hydroxy-3-methoxy benzylidene)amino)benzoicacid, 3 and their Ni(II), Cu(II), Co(II), Zn(II), Fe(II), Mn(II) complexes have been reported. Their spectral properties were studied in solution an...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
In conclusion, the isolated endophytic A. nidulans, A. fumigatus, and A. flavus from Ocimum basilicum are promising sources for bioactive compounds.PMID:34661866 | DOI:10.1007/s12010-021-03702-w
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, we aimed to investigate for the first time antimicrobial and antimutagenic activities new two Schiff bases, obtained from a primary amine (p-toluidine, o-toluidine) and an aldehyde (Helicin). Synthesized compounds characterized with elemental analysis, fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometry. 1H-13C nuclear magnetic resonance spectroscopy. Antimutagenic activity was evaluated by micronuclei assay. Antimicrobial activity of Schiff bases have been demonstrated against pathogenic four Gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermis, Micrococcus lute...
Source: An Acad Bras Cienc - Category: Science Authors: Source Type: research
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