Synthesis and antimicrobial activity of ursolic acid ester derivatives

In this study, sixteen esters ( 1 - 16 ) were synthesized from ursolic acid using DIC/DMAP and characterized by infrared and nuclear magnetic resonance ( 1 H- and 13 C-NMR) spectrometry. All ursolic acid esters were evaluated against the bacteria Bacillus cereus , Staphylococcus aureus , Escherichia coli , Salmonella typhimurium , and the yeast Candida albicans . Six compounds are herein described for the first time ( 3 , 9 , 11 , 13 , 14 and 16 ) with reaction yields up to 91.6%. Compounds 11 (3 β- (3,4-dimethoxybenzoyl) ursolic acid) and 15 (3 β -nicotinoyl ursolic acid) displayed promising antifungal activity, with inhibition of C. albicans growth of 93.1 and 95.9%, respectively.PMID:34793623 | DOI:10.1002/cbdv.202100566
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research