FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells.

CONCLUSIONS: FOXA1 may be associated with methylation of the tumor suppressor genes promoter through changing DNMTs expression. FOXA1 could be a potential demethylation target for prevention and treatment of breast cancer. PMID: 25755696 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25755696?dopt=Abstract

Source: Clinical Breast Cancer - March 13, 2015 Category: Cancer & Oncology Authors: Zheng L, Qian B, Tian D, Tang T, Wan S, Wang L, Zhu L, Geng X Tags: Int J Clin Exp Pathol Source Type: research