Effective synthesis of novel dihydrobenzisoxazoles bearing 2-aminothiazole moiety and antiproliferative activity evaluation of their acylated derivatives

Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01614H, PaperYuri A. Piven, Alexander M. Scherbakov, Margarita A. Yastrebova, Danila V. Sorokin, Yuri Yu. Shchegolev, Anton E. Matous, Veronica G. Zinovich, Tatyana S. Khlebnicova, Fedor A. Lakhvich Effective method of synthesis of 8-aryl-4,5-dihydrothiazolo[4',5':3,4]benzo[1,2-c]isoxazol-2-amines was developed. The method includes α-keto bromination of 3-aryl-6,7-dihydrobenzo[c]isoxazol-4(5H)-ones followed by condensation of obtained bromo derivatives with thiourea in acetonitrile with 92-98% yield. Using... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research