A systematic review and meta-analysis of murine models of uremic cardiomyopathy

Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally, animal studies are used to reveal the underlying pathological mechanism, although variable CKD models, mouse strains and readouts may reveal diverse results. Here, we systematically reviewed 88 studies and performed meta-analyses of 52 to support finding suitable animal models for future experimental studies on pathological kidney-heart crosstalk during uremic cardiomyopathy.

Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P.C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joach Tags: Basic Research Source Type: research