Urinary sodium/creatinine ratio is a predictor for fractional sodium excretion and related to age in patients with cystic fibrosis

As result of the cystic fibrosis transmembrane regulator (CFTR) dysfunction, patients with cystic fibrosis (CF) lose 2 –4 times more salt in their sweat [1]. Siegentahler et al. demonstrated that CF patients, in contrast to healthy controls, were unable to decrease salt losses in sweat when confronted with salt deprivation [2]. Hyponatremic, hypochloremic alkalosis with or without hypokalemia, also known as pseud o-Bartter syndrome, can be observed in patients with CF confronted with situations leading to inadequate salt and fluid intake or increased losses through the gastro-intestinal tract or sweating.

Source: Journal of Cystic Fibrosis - November 18, 2021 Category: Respiratory Medicine Authors: Dimitri Declercq, Lieselot Peremans, Michiel Glorieus, Yannick Vande Weygaerde, Heidi Schaballie, Eva Van Braeckel, Evelien Snauwaert, Sabine Van daele, Stephanie Van Biervliet Source Type: research