Glial Pathology in Bipolar Disorder: Potential Therapeutic Implications.

Glial Pathology in Bipolar Disorder: Potential Therapeutic Implications. CNS Neurosci Ther. 2015 Mar 9; Authors: Dong XH, Zhen XC Abstract Bipolar disorder (BD) is a chronic and severe mental disorder with recurrent episodes of mania and depression. In addition to neuronal alterations, accumulating evidences have revealed the importance of glial system in pathophysiology and phenotype of the illness. Postmortem studies have repeatedly demonstrated the alterations in glial cells and its functions in patients with BD. The activated microglia and inflammatory cytokines are proposed to be the potential biomarkers that may help to predict disease exacerbation in BD. On the other hand, anti-BD drugs have been shown to produce profound effects on glial activity, which not only contributes to the therapeutic efficacy, but may also provide a potential target for the drug development of BD. We will focus on the recent development of glial abnormalities and potential therapeutic benefits targeted to glial modulation in BD. PMID: 25753128 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research

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ConclusionsThere is an asymmetry between the increase in the use of antipsychotics in BD and the lack of data regarding the SRA. Phenomenologically, SRA in BD is similar to that found in schizophrenic subjects. Some of these symptoms may be misdiagnosed as depressive symptoms. The existing data show that SRA has a strong correlation with treatment compliance as well as a promising way to develop theoretical paradigms for these disorders.
Source: European Psychiatry - Category: Psychiatry Source Type: research
ConclusionAnimal models that disrupt ion regulation are more inclined to model both mania and depression; and are thus the most promising models available. However, other models are important for demonstrating mechanisms in important pathophysiologic aspect of bipolar disorder.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
We present two cases of schizophrenia, treated with lurasidone developing anemia after variable period of treatment and reverting after stopping lurasidone. These cases emphasize the timely monitoring of blood parameters for prevention or early detection of anemia in patients treated with lurasidone.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
 It seems like every day there is another mass shooting in the news: Newtown, Parkland, Odessa, Dayton. And most of these news reports allude to the shooter having mental illness. But is this true? Common wisdom holds that someone must be mentally ill to do such a thing. But is it really that simple? Join us for a nuanced discussion with Dr. John Grohol, the founder of, as he explains how media bias and slanted reporting have contributed to the myths and misunderstandings of who is violent in America. SUBSCRIBE &REVIEW Guest information for ‘Mass Shootings and Mental Illness’ Podca...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Interview Mental Health and Wellness Podcast Psychiatry Psychology The Psych Central Show Violence and Aggression Source Type: blogs
Publication date: Available online 10 September 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Anne J. Bjertrup, Nellie K. Friis, Kamilla W. MiskowiakAbstractMothers’ sensitive responses to their infants have evolutionary importance and are likely hardwired into the maternal brain. Mood disorders are associated with aberrant neural processing of emotion in regions overlapping with ‘maternal sensitivity networks’ and this could compromise maternal processing of infant signals. This systematic review aimed to integrate findings from studies of neural responses to infant stimuli in healthy mot...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
ConclusionsThe strategy of using glutamatergic modulators as therapeutic agents requires a better understanding of the role of glutamate in the pathophysiology of depression. Gaining such understanding is a challenge because it entails evaluating different targets as well as the effects of these modulators on the kinetics of glutamate uptake. Essentially, glutamate transport is a dynamic process and, currently, it is still necessary to develop new approaches to assay glutamate in the synaptic cleft.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Suicide is common in Bipolar Disorder (BD). The estimated prevalence is 20-30 times higher in BD patients than in the general population and almost half of the individuals with BD attempt suicide during their lives 1. An increasing number of stu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Commentary Source Type: news
Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still uncl...
Source: Annals of General Psychiatry - Category: Psychiatry Authors: Tags: Primary research Source Type: research
Bipolar disorder is associated with the highest risk of completed suicide of all mental disorders. The suicide mortality of people with bipolar disorder is approximately 25 times higher than the general population. No approved pharmacological strategies fo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Çınar R, Sönmez MB Abstract Bupropion is a selective norepinephrine and dopamine reuptakeinhibitor. It is used in the treatment of depression and nicotineaddiction. When compared to the other antidepressants, bupropion hasa relatively lower risk of triggering shift to hypomania or mania in bipolardepression treatment. Here we report two cases of bipolar depressionpatients with manic shift when bupropion was used as an adjunct tomood stabilizer treatment. The first was a 43-year old female patient.Manic symptoms occurred after bupropion was added to lithium andquetiapine treatment for bipolar disorder ...
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
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