Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α-Synuclein

Chemphyschem. 2021 Nov 15. doi: 10.1002/cphc.202100796. Online ahead of print.ABSTRACTThe front cover artwork is provided by the group of Liming Ying at Imperial College London. The image shows that N-terminal acetylation of α-synuclein shifts the binding from the N-terminus to His50 and significantly slows down the binding reaction. Read the full text of the Article at 10.1002/cphc.202100651.PMID:34779565 | DOI:10.1002/cphc.202100796

Source: Chemphyschem - November 15, 2021 Category: Chemistry Authors: Xiangyu Teng Alena Sheveleva Floriana Tuna Keith R Willison Liming Ying Source Type: research