Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients

In conclusion, we show that immunoglobulin and autoreactive antibody levels are not significantly different in COPD LTx recipients that develop PGD. However, using a novel IgG glycomic analysis we were able to demonstrate multiple significant increases in IgG1 specific N-glycan signatures that were predictive of PGD development. Taken together, these data represent a potential novel method for identifying COPD patients at risk for PGD development and may provide clues to mechanisms by which antibody N-glycan signatures could contribute to antibody-mediated PGD pathogenesis.PMID:34767945 | DOI:10.1016/j.trim.2021.101491

Source: Transplant Immunology - November 12, 2021 Category: Transplant Surgery Authors: Alexander McQuiston Danielle Scott Dianna Nord Logan Langerude Andres Pelaez Tiago Machuca Anand Mehta Jason D Chrisie Peggi Angel Carl Atkinson Source Type: research