LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression

ConclusionIn summary, LINC02381 repressed osteogenic differentiation of hUS-MSCs through sponging miR-21 to enhance KLF12-mediated inactivation of Wnt/ β-catenin pathway, indicating that LINC02381 might be a therapeutic target for osteoporosis.
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research