Granulocytosis, a Paraneoplastic Syndrome Associated With Non-Glandular Squamous Cell Carcinomas (NGSCC) in the Tg.rasH2 Studies

Toxicol Pathol. 2021 Nov 7:1926233211055717. doi: 10.1177/01926233211055717. Online ahead of print.ABSTRACTNon-glandular squamous cell carcinoma (NGSCC) is an extremely rare tumor in Tg.raH2 mice. There have been 5 NGSCC in 1615 control male mice (0.31%) and 2 NGSCC in 1560 control female mice (0.13%) on 26-week carcinogenicity studies, with a range of 0 to 1 of per group per sex in each study without statistical significance in 52 male and 51 female studies conducted in Tg.rasH2 mice. Every case of NGSCC was accompanied by profound granulocytosis.PMID:34747286 | DOI:10.1177/01926233211055717
Source: Toxicologic Pathology - Category: Pathology Authors: Source Type: research