Cancers, Vol. 13, Pages 5694: Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Cancers, Vol. 13, Pages 5694: Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis Cancers doi: 10.3390/cancers13225694 Authors: Gábor Cserni Cecily M. Quinn Maria Pia Foschini Simonetta Bianchi Grace Callagy Ewa Chmielik Thomas Decker Falko Fend Anikó Kovács Paul J. van Diest Ian O. Ellis Emad Rakha Tibor Tot European Working Group for Breast Screening Pathology European Working Group for Breast Screening Pathology Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent course. This review on behalf of the European Working Group for Breast Screening Pathology reviews the literature on the special histological types of BC that are reported to have a triple negative phenotype and indolent behaviour. These include adenoid cystic carcinoma of classical type, low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade mucoepidermoid carcinoma, secretory carcinoma, acinic cell carcinoma, and tall cell carcinoma with reversed polarity. The pathological and known molecular features as well as clinical data including treatment and prognosis of these special TNBC subtypes are summarised and it is concluded that many patients with these rar...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research

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Int J Clin Exp Pathol. 2021 Mar 1;14(3):355-362. eCollection 2021.ABSTRACTMetaplastic breast carcinoma is a rare invasive breast cancer. Metaplastic breast carcinoma is mainly characterized by an epithelial or mesenchymal cell population mixed with adenocarcinoma. We collected 26 cases of metaplastic breast carcinoma in the First Affiliated Hospital of Bengbu Medical College from 2008 to 2014. Tumor size, tumor grade, vascular invasion, ER/PR status, histologic classification, and HER2/neu status were assessed for all cases and the literature was reviewed. Clinicopathologic characteristics of patients diagnosed with metapl...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Source Type: research
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