Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects

CONCLUSIONS: Ustekinumab inhibits the inflammatory cytokines IL-12P40 and IL-23, while curcumin has antioxidant effects (increasing SOD, GPx, and CAT levels) with anti-inflammatory effects (decreasing the proinflammatory cytokine TNF-α and IL-17). Therefore, CUC could be an excellent cost-effective regimen that can improve the treatment of psoriasis by the synergistic effects of CUC.PMID:34749565 | DOI:10.1080/15569527.2021.2003377

Source: Cutaneous and Ocular Toxicology - November 9, 2021 Category: Toxicology Authors: Ayman M Mousa Fahad A Alhumaydhi Ahmed A H Abdellatif Waleed Al Abdulmonem Mohammad S AlKhowailed Suliman A Alsagaby Osamah Al Rugaie Abdullah M Alnuqaydan Abdullah Sm Aljohani Mohammad Aljasir Ameen S S Alwashmi Khaled E A Soliman Mohamad Y R Yosof Sayed Source Type: research