Elaboration of copper-oxygen mediated CH activation chemistry in consideration of future fuel and feedstock generation.

Elaboration of copper-oxygen mediated CH activation chemistry in consideration of future fuel and feedstock generation. Curr Opin Chem Biol. 2015 Mar 7;25:184-193 Authors: Lee JY, Karlin KD Abstract To contribute solutions to current energy concerns, improvements in the efficiency of dioxygen mediated CH bond cleavage chemistry, for example, selective oxidation of methane to methanol, could minimize losses in natural gas usage or produce feedstocks for fuels. Oxidative CH activation is also a component of polysaccharide degradation, potentially affording alternative biofuels from abundant biomass. Thus, an understanding of active-site chemistry in copper monooxygenases, those activating strong CH bonds is briefly reviewed. Then, recent advances in the synthesis-generation and study of various copper-oxygen intermediates are highlighted. Of special interest are cupric-superoxide, Cu-hydroperoxo and Cu-oxy complexes. Such investigations can contribute to an enhanced future application of CH oxidation or oxygenation processes using air, as concerning societal energy goals. PMID: 25756327 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research