Plaque progression: Where, why, and how fast? A review of what we have learned from the analysis of patient data from the PARADIGM registry

Ischemic heart disease is the most common cause of mortality worldwide. The pathophysiology of myocardial infarction relates to temporal changes of atherosclerotic plaque culminating in plaque rupture, erosion or hemorrhage and the subsequent thrombotic response. Coronary computed tomographic angiography (CCTA) provides the ability to visualize and quantify plaque, and plaque progression can be measured on a per-patient basis by comparing findings of serial CCTA. The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry was established with the objective of identifying patterns of plaque progression in a large population.

Source: Journal of Cardiovascular Computed Tomography - November 13, 2021 Category: Radiology Authors: Praveen Indraratna, Elina Khasanova, Gaurav S. Gulsin, Georgios Tzimas, Hidenobu Takagi, Keun-Ho Park, Fay Y. Lin, Leslee J. Shaw, Sang-Eun Lee, Jagat Narula, Jeroen J. Bax, Hyuk-Jae Chang, Jonathon Leipsic, PARADIGM investigators Source Type: research