Expression of the growth hormone secretagogue receptor 1a (GHS ‐R1a) in the brain

The review presents data on the expression of GHS-R1a in the brain in model animals and in the human brain. Every year, new data appear showing that GHS-R1a plays an important role on physiological processes. Numerous data indicate the involvement of the receptor in the development of neurodegenerative process in various pathological conditions of the brain. AbstractThe review presents data on the expression of growth hormone secretagogue receptor 1a (GHS-R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain. Studies show widespread distribution of the receptor in the brain, which evidences the involvement of the receptor in many physiological processes. Using various organisms, data have been obtained regarding the participation of the GHS-R1a in the regulation of the anti- and pro-inflammatory response, proliferation, and apoptosis. It is known that the receptor plays an important role in eating behavior and is also involved in the pathogenetic mechanisms of drug addiction, obesity, and chronic alcohol consumption. Based on this, research is underway with the use of various therapeutic agents that can be used for the pharmacological correction of these conditions. This review also presents hypothetical pathways of intracellular signaling, in which GHS-R1a may participate. A complete understanding of these mechanisms has not yet been reached. The ghrelin intracellular signaling seem to be specific to brain region and, probably, als...
Source: Physiological Reports - Category: Physiology Authors: Tags: REVIEW Source Type: research

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DiscussionAddictive-like behaviors seemed to be maintained by trait levels of emotion dysregulation, albeit channeled via trait levels of compulsivity and/or impulsivity. The role of emotion dysregulation may help us to understand why addictive-like behaviors can be difficult to change in both clinical and nonclinical groups, and may be informative for treatment-planning in patients where these behaviors are present. Our findings support adopting a more dimensional approach to psychiatric classification by focusing psychological facets such as those studied.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The World Food Programme distributing food in El Salvador. The second of the UN's 17 Sustainable Development Goals is to end hunger, achieve food security and improved nutrition and promote sustainable agriculture. Credit: WFP/David FernandezBy Trish CotterMELBOURNE, Sep 21 2021 (IPS) COVID-19 has exposed serious vulnerabilities in how people around the world access and consume food. One of the more alarming trends is the significant increase in the consumption of foods that may be tasty and convenient, but harm our heath. These ultra-processed products include sugary drinks, snack foods, frozen meals, packaged breads and ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Climate Change Editors' Choice Featured Food and Agriculture Food Security and Nutrition Global Headlines Health IPS UN: Inside the Glasshouse Poverty & SDGs TerraViva United Nations Source Type: news
Conclusion: The present study provides preliminary support for the long-term efficacy of imaginal retraining on craving for tobacco but not on smoking behaviour, highlighting the importance of multimodal treatment concepts in smoking cessation that target a variety of maintaining factors. Future studies need to investigate the long-term efficacy of the intervention in prospective RCTs that test alternative ways of conveying the technique to improve adherence.Eur Addict Res
Source: European Addiction Research - Category: Addiction Source Type: research
Conclusion: This study offers insight into the disease burden of HS in an Italian population. Our results underline the impact of QoL evaluation, also with the use of the HIDRAdisk, in clinical routine as a support to validated severity clinical and instrumental indexes for a “360-degree” assessment of HS patient’s burden of disease.Dermatology
Source: Dermatology - Category: Dermatology Source Type: research
Appetite. 2021 Aug 26;168:105665. doi: 10.1016/j.appet.2021.105665. Online ahead of print.ABSTRACTINTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is associated with binge eating (BE), food addiction (FA), and obesity/higher BMI in individuals without alcohol use disorder (AUD). ADHD is highly prevalent in patients with AUD, but it is unknown whether the presence of comorbid AUD might change the nature of the association between ADHD, BE, FA and BMI (food and alcohol may either compete for the same brain neurocircuitry or share vulnerability risk factors). Here, we filled this gap by testing the association be...
Source: Appetite - Category: Nutrition Authors: Source Type: research
Mol Biol (Mosk). 2021 Jul-Aug;55(4):578-584. doi: 10.31857/S0026898421040029.ABSTRACTThe review presents data on the expression of ghrelin receptor GHS-R1a in the brain in model animals (Danio rerio, rodents, primates), and in the human brain. Studies show widespread localization of GHS-R1a in the brain, which indicates the involvement of the receptor in many physiological processes. Using various models, information has been obtained regarding the participation of the receptor in the regulation of the pro- and anti-inflammatory response, apoptosis and proliferation. It is known that the ghrelin receptor plays an important...
Source: Molekuliarnaia Biologiia - Category: Molecular Biology Authors: Source Type: research
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