Degradation of the Endothelial Glycocalyx Contributes to Metabolic Acidosis in Children Following Cardiopulmonary Bypass Surgery

CONCLUSIONS: Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary bypass. In addition, cleavage of heparan sulfate was associated with renal dysfunction, capillary leak, and global markers of cardiovascular dysfunction. These data highlight the importance of designing translational therapies to protect the glycocalyx in cardiopulmonary bypass.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

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[spotlight] High blood pressure (hypertension) is the leading cause of heart disease and premature death worldwide, according to an article in Nature. While it is not specifically listed on the World Health Organization's list of top 10 causes of death, it is an underlying cause of heart disease and stroke, both of which are on the list.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Here are some ways to help when a partner, family member, or close friend has been diagnosed with heart disease.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Purpose of review Nearly half of all Americans with chronic kidney disease (CKD) also have type-2-diabetes (T2D). Whereas traditional and emerging pharmacotherapies are increasingly frequently used for the management of CKD in diabetes (CKD/DM), the role of integrated or multimodal interventions including the potentially synergistic and additive effect of diet and lifestyle modifications in addition to pharmacotherapy has not been well examined, in sharp contrast to the well-known integrated approaches to heart disease. Recent findings Low-carbohydrate low-fat diets are often recommended in T2D, whereas low-prot...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Ekamol Tantisattamo, Ramy M. Hanna and Kamyar Kalantar-Zadeh Source Type: research
Front Mol Biosci. 2021 Nov 18;8:784910. doi: 10.3389/fmolb.2021.784910. eCollection 2021.ABSTRACTEnvironmental exposures represent a significant health hazard, which cumulatively may be responsible for up to 2/3 of all chronic non-communicable disease and associated mortality (Global Burden of Disease Study and The Lancet Commission on Pollution and Health), which has given rise to a new concept of the exposome: the sum of environmental factors in every individual's experience. Noise is part of the exposome and is increasingly being investigated as a health risk factor impacting neurological, cardiometabolic, endocrine, an...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
CONCLUSION: What we can retain from our case is that SMA can be the cause or consequence of coronary ischemia, so we must be vigilant in patients with an atypical clinical presentation.PMID:34868571 | PMC:PMC8626648 | DOI:10.1016/j.amsu.2021.103042
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
CONCLUSIONS: IVUS enhanced our diagnostic interpretation and identified occult lesions not visualized by angiography. IVUS was valuable in guiding and defining the endpoints of these interventions.PMID:34866050
Source: The Journal of Invasive Cardiology - Category: Cardiology Authors: Source Type: research
J Oncol. 2021 Nov 24;2021:6103092. doi: 10.1155/2021/6103092. eCollection 2021.ABSTRACTThe study focused on the risk factors of postoperative arrhythmia and lung infection and the preventive effects of targeted low-molecular-weight heparin (LMWH) on the occurrence of deep venous thrombosis (DVT) in patients with esophageal/cardia cancer. In this article, 82 patients who were pathologically diagnosed with esophageal/cardia cancer and underwent surgical treatment were selected as the research subjects. According to the different preoperative treatment methods, the patients were divided into the control group (without anticoa...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
HIGH cholesterol is a concern for a lot of people in the UK. It is a condition that has to be managed carefully to avoid the development of any serious conditions. An American study has now found that heart disease may not be the only thing you're at risk of with high cholesterol.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Indian Heart J. 2021 Dec 2:S0019-4832(21)00447-8. doi: 10.1016/j.ihj.2021.11.184. Online ahead of print.ABSTRACTOBJECTIVE: Patients with multi-vessel coronary artery disease (MVD) compared to single-vessel coronary artery disease (CAD) have more comorbidities and poor in-hospital outcomes. We aim to analyze MVD-AMI patients regarding clinical data and short-term outcomes.METHODS: This is a retrospective analysis of the prospectively collected data registry, a single-center study reviewing the clinical details and hospital outcome measures of AMI patients referred to our center for early revascularization from 2016 to 2019....
Source: Indian Heart J - Category: Cardiology Authors: Source Type: research
AN AUSTRALIAN study comparing medication and nutrition found that diet has the more profound impact on controlling diabetes, stroke and heart disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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