Risk factors for nosocomial methicillin resistant Staphylococcus aureus (MRSA) colonization in a neonatal intensive care unit: A Case-control study

Persistently circulating MRSA clone in NICU. • Risk factors for MRSA colonization, independent of length of stay&gestational age. • Colonization pressure, lower ATP pass rate are associated with acquisition of colonization. • Higher acuity of care is also associated with acquisition of colonization. • In a multivariable model, only colonization pressure was significantly associated. To determine risk factors for MRSA col onization in a Level IV Neonatal Intensive Care Unit (NICU) independent of length of stay and gestational age in the context of a persistently circulating MRSA clone. Retrospective matched case-control study. Level IV NICU Infants admitted between April 4,2017- March 31,2018. Based on weekly surveil lance cultures, infants who acquired MRSA were matched 1:1 with MRSA-negative control infants by duration of exposure (length of stay) and gestational age to determine risk factors for acquisition. Fifty case infants were matched with controls. Isolates from 45 of the 50 cases were mupirocin-resista nt and related by pulse-field gel electrophoresis. On matched univariable analysis, the following were significantly associated with a risk for MRSA acquisition: 1.Bed location in the acute area(P = 0.03), 2.Requirement of any level of respiratory support during the week prior to MRSA detection(P = 0.04), 3.Higher ATP pass rate (a measure of effectiveness of cleaning) during the week of and week prior(P = 0.01), 4.Higher MRSA colonization pressu...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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ConclusionsOur meta-analysis did not show any beneficial effects from IPC interventions on MRSA reductions in LTCFs. Our findings highlight that the effectiveness of interventions in these facilities is likely conditional on resource availability —particularly decolonization and barrier precautions, due to their potential adverse events and uncertain effectiveness. Hence, administrative engagement is crucial for all effective IPC programmes. LTCFs should consider a pragmatic approach to reinforce standard precautions as routine practice an d implement barrier precautions and decolonization to outbreak responses only.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
CONCLUSION: The excellent activity of ceftobiprole against MRSA would have major implications in management of the patients with serious infections, as an empirical treatment or alternative to vancomycin. Ceftobiprole has a very low activity against MDR P. aeruginosa, and its susceptibility should be tested prior to use for treatment.PMID:35022281 | DOI:10.15537/smj.2022.43.1.20210587
Source: Saudi Medical Journal - Category: Middle East Health Authors: Source Type: research
In conclusion, Tys inhibits lung EC barrier disruption and proinflammatory signaling induced by MRSA in vitro and attenuates acute lung injury induced by MRSA in vivo. These results support the potential utility of Tys as a novel ARDS therapeutic strategy.PMID:35015568 | DOI:10.1152/ajplung.00100.2021
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Source Type: research
In this study, aiming at developing novel and more effective agents, a series of fascaplysin derivatives and their corresponding β-carboline precursors have been synthesized. Then their antibacterial/antibiofilm activity and mechanisms against MRSA were investigated for the first time. The results showed that most fascaplysins rather than β-carboline precursors exhibit superior antimicrobial activity against MRSA ATCC43300, demonstrating the important role of cationic five-ring coplanar backbone playing in antibacterial activity. Among them, 14 and 18 are the most potent compounds with MIC value of 0.098 μg/ml...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Conclusions. 1. Regarding the results of our patients, reinsertion of autoclaved femoral and tibial prostheses together with a new same brand polyethylene insert with teicoplanin loaded bone cement can be used cautiously in the management of periprosthetic deep infection of TKA. 2. That is because patients might not want the second stage reimplantation. 3. We believe that the refusal of patients to undergo the surgery shows that the single-stage treatment is effective.PMID:35008033 | DOI:10.5604/01.3001.0015.6359
Source: Ortopedia, Traumatologia, Rehabilitacja - Category: Orthopaedics Authors: Source Type: research
Trop Biomed. 2021 Dec 1;38(4):484-490. doi: 10.47665/tb.38.4.093.ABSTRACTIn our present study, the hexane fraction from the root of the Thai medicinal plant Strophioblachia fimbricalyx Boerl. was purified and the purification led to the isolation of 3-acetylaleuritolic acid, trigonostemone and 3,6,9-trimethoxyphenanthropolone. The aims of this work are to evaluate antibacterial activity of these three isolated compounds from our local plant and to study their mechanism of actions toward target pathogenic bacteria (Gram positive and Gram negative bacteria). The antibacterial activity of isolated compounds was primary screen...
Source: Tropical Biomedicine - Category: Tropical Medicine Authors: Source Type: research
Biomacromolecules. 2022 Jan 10. doi: 10.1021/acs.biomac.1c01368. Online ahead of print.ABSTRACTHospital-acquired infections are a serious threat to the recovery of patients. To prevent such infections, an antibacterial coating is an effective method to eliminate bacterial colonization on healthcare-related surfaces. Herein, we report an antibacterial hydrogel composed of silver-containing polyoxometalate (AgP5W30 POM) and carboxymethyl chitosan (CMC). The silver ion is encapsulated inside the POM cage and demonstrates long-lasting bacteriostasis after repeated exposure to both Gram-positive and Gram-negative bacteria. The ...
Source: Biomacromolecules - Category: Biochemistry Authors: Source Type: research
Trop Biomed. 2021 Dec 1;38(4):484-490. doi: 10.47665/tb.38.4.093.ABSTRACTIn our present study, the hexane fraction from the root of the Thai medicinal plant Strophioblachia fimbricalyx Boerl. was purified and the purification led to the isolation of 3-acetylaleuritolic acid, trigonostemone and 3,6,9-trimethoxyphenanthropolone. The aims of this work are to evaluate antibacterial activity of these three isolated compounds from our local plant and to study their mechanism of actions toward target pathogenic bacteria (Gram positive and Gram negative bacteria). The antibacterial activity of isolated compounds was primary screen...
Source: Tropical Biomedicine - Category: Tropical Medicine Authors: Source Type: research
Conclusions. 1. Regarding the results of our patients, reinsertion of autoclaved femoral and tibial prostheses together with a new same brand polyethylene insert with teicoplanin loaded bone cement can be used cautiously in the management of periprosthetic deep infection of TKA. 2. That is because patients might not want the second stage reimplantation. 3. We believe that the refusal of patients to undergo the surgery shows that the single-stage treatment is effective.PMID:35008033 | DOI:10.5604/01.3001.0015.6359
Source: Ortopedia, Traumatologia, Rehabilitacja - Category: Orthopaedics Authors: Source Type: research
Biomacromolecules. 2022 Jan 10. doi: 10.1021/acs.biomac.1c01368. Online ahead of print.ABSTRACTHospital-acquired infections are a serious threat to the recovery of patients. To prevent such infections, an antibacterial coating is an effective method to eliminate bacterial colonization on healthcare-related surfaces. Herein, we report an antibacterial hydrogel composed of silver-containing polyoxometalate (AgP5W30 POM) and carboxymethyl chitosan (CMC). The silver ion is encapsulated inside the POM cage and demonstrates long-lasting bacteriostasis after repeated exposure to both Gram-positive and Gram-negative bacteria. The ...
Source: Biomacromolecules - Category: Biochemistry Authors: Source Type: research
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