Efficacy of Repetitive Transcranial Magnetic Stimulation for Acute Central Post-stroke Pain: A Case Study

In this study, we present a case of a patient with thalamic stroke with acute onset of pain and paresthesia who was responsive to rTMS. After a right thalamic stroke, a 32-year-old woman presented with drug-resistant pain and paresthesia on the left side of the body. There were no motor or sensory deficits, except for blunted thermal sensation and allodynia on light touch. Ten daily sessions were performed, where 10 Hz rTMS was applied to the hand area of the right primary motor cortex, 40 days after stroke. Before rTMS treatment (T0), immediately after treatment conclusion (T1), and 1 month after treatment (T2), three pain questionnaires were administered, and cortical responses to single and paired-pulse TMS were assessed. Eight healthy participants served as controls. At T0, when the patient was experiencing the worst pain, the excitability of the ipsilesional motor cortex was reduced. At T1 and T2, the pain scores and paresthesia' spread decreased. The clinical improvement was paralleled by the recovery in motor cortex excitability of the affected hemisphere, in terms of both intra- and inter-hemispheric connections. In this subacute central post-stroke pain case, rTMS treatment was associated with decreased pain and motor cortex excitability changes.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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In this report, failure to recognize the upper limb ischemia would have led to delayed treatment, potentially resulting in the fistula's complete thrombosis and further limb ischemia. We highlight the importance of a diagnosis method like Doppler ultrasound, which allows for rapid evaluation at the patient's bedside.PMID:35000475 | DOI:10.1177/11297298211067686
Source: The Journal of Vascular Access - Category: Surgery Authors: Source Type: research
In conclusion, our studies suggested that engrafted OPCs promoted the recovery after ischemic stroke by enhancing endogenous oligodendrogenesis, neurite growth, and synaptogenesis; the last two being mediated by the Netrin-1/DCC axis. Rejuvenating the Gut Microbiome of Aged Mice in Various Ways https://www.fightaging.org/archives/2022/01/rejuvenating-the-gut-microbiome-of-aged-mice-in-various-ways/ The gut microbiome changes with age in a number of different ways that are detrimental to long term health. Firstly, inflammatory microbial populations increase in number, rousing the immune system to constant...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Funding Opportunity RFA-NS-22-034 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
J Biochem. 2021 Dec 30:mvab143. doi: 10.1093/jb/mvab143. Online ahead of print.ABSTRACTIn addition to diurnal rhythms in physiology and behavior, a variety of pathological conditions also exhibit marked day-night changes in symptom intensity, exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and chronic pain disorders. Currently, novel therapeutic approaches are facilitated by the development of chemical compounds targeted to key proteins that cause diurnal exacerbation of pathological events. Neuropathic pain is a chronic condition that occurs by tumor-induced ne...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
RARITAN, NJ, Dec. 20, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved two pediatric indications for XARELTO® (rivaroxaban): the treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients from birth to less than 18 years after at least five days of initial parenteral (injected or intravenous) anticoagulant treatment; and thromboprophylaxis (prevention of blood clots and blood-clot related events) in children aged two years and older with congenital heart disease wh...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
The research targets people with complex regional pain syndrome, post-stroke pain, and other pain-induced conditions.
Source: mobihealthnews - Category: Information Technology Source Type: news
Ann Vasc Surg. 2021 Dec 9:S0890-5096(21)00932-8. doi: 10.1016/j.avsg.2021.11.008. Online ahead of print.ABSTRACTBACKGROUND: Chronic limb-threatening ischemia (CLTI), which presents with ischemic rest pain, ulceration, or gangrene, is a complex form of peripheral artery disease that can cause mortality and amputation. C-reactive protein (CRP), an inflammatory marker, indicates vascular inflammation resulting from the cytokine-dependent inflammatory process in the arterial wall and arterial atherosclerosis resulting from the inflammation. Lower albumin levels are also associated with peripheral artery disease. We investigate...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
ConclusionsAlthough the results support the role of surgery in the management of nhSPCs, they have to be interpreted with a great deal of caution as the current evidence is limited, consisting only of case reports and retrospective surgical series. Inherent to such studies are inhomogeneity and incompleteness of data, selection bias and bias related to assessment of outcome carried out by the treating surgeon in the majority of cases. Prospective studies with patient-reported and objective outcome assessment are needed to provide higher level of evidence.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Digital media&downloads Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief Researchers targeted a common sodium ion channel to reverse pain and saw positive results that could lead to a nonaddictive solution to treat pain. Today University of Arizona Health Sciencespain-relief-web.jpgHealthBIO5College of Medicine - TucsonExpertsResearch Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizona.edu520-539-4152Researchers at the  University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed t...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
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