Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.

Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially, vitamin K uptake and distribution into circulating lipoproteins after a single administration of vitamin K1 plus K2 (menaquinone 4 and menaquinone 7, respectively) was determined in patients on dialysis therapy and healthy individuals. The patients incorporated very little menaquinone 7 but more menaquinone 4 into high density lipoprotein (HDL) and low density lipoprotein particles than did healthy individuals.

Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, J ürgen Floege Tags: basic research Source Type: research