Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An Accelerated Workflow for Evaluation of Lead Monoclonal Antibodies

CONCLUSION: An accelerated HDX-MS epitope screening workflow was developed. The 'screening' workflow successfully characterized five (out of six attempted) novel epitopes on the PRN antigen; information that can be used to support vaccine antigenicity assays. This article is protected by copyright. All rights reserved.PMID:34747565 | DOI:10.1002/biot.202100358
Source: Biotechnology Journal - Category: Biotechnology Authors: Source Type: research
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