Inflammation biomarkers in sputum for clinical trials in cystic fibrosis: current understanding and gaps in knowledge

Sputum biomarkers hold promise as a direct measure of inflammation within the cystic fibrosis (CF) lung, but variability in study design and sampling methodology have limited their use. A full evaluation of the reliability, validity and clinical relevance of individual biomarkers is required to optimise their use within CF clinical research.

Source: Journal of Cystic Fibrosis - November 9, 2021 Category: Respiratory Medicine Authors: Agathe Lepissier, Charlotte Addy, Kate Hayes, Sabrina Noel, St éphanie Bui, Pierre-Régis Burgel, Lieven Dupont, Olaf Eickmeier, Michael Fayon, Teresinha Leal, Carlos Lopes, Damian G. Downey, Isabelle Sermet-Gaudelus Source Type: research