The efficacy, safety, and cost-effectives of combined administration of Intravenous and Local Tranexamic Acid in the management of Patients Undergoing Primary Total Hip Arthroplasty: A prospective, blinded and randomized clinical study

Acta Orthop Traumatol Turc. 2021 Sep;55(5):422-427. doi: 10.5152/j.aott.2021.20397.ABSTRACTOBJECTIVE: The aim of this study was to compare the efficacy, safety, and cost-effectiveness of combined administration of intravenous and local tranexamic acid with those of either intravenous or local administrations in patients undergoing primary total hip arthroplasty (THA).METHODS: This prospective, blinded, and randomized clinical study was performed on patients undergoing unilateral primary THA from September 2018 to December 2019. A total of 90 patients were included and prospectively allocated to one of three groups: the combined group (n= 30, 14 male, 16 female; mean age = 54.9 ± 12 years), intravenous (IV) group (n = 30, 13 male, 17 female; mean age = 54.9 ± 12.3 years), and local group (n = 30, 13 male, 17 female; 50.3 ± 12.3). Tranexamic acid was used systemically by IV application (15mg/kg) in IV group, locally in the surgical field (2g) in local group as well as combined systemic and local together in combined group. The amount of blood loss, number of erythrocyte suspension transfusion, and changes in hemoglobin and hematocrit levels were documented accordingly. The estimated mean tranexamic acid and erythrocyte suspensions cost, extra nurse care, monitoring and laboratory costs associated with blood transfusion, and total hospital costs were compared among groups.RESULTS: No differences existed in hemoglobin and hematocrit levels after surgery among...
Source: Acta Orthopaedica et Traumatologica Turcica - Category: Orthopaedics Authors: Source Type: research

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Source: Blood Transfusion - Category: Hematology Authors: Source Type: research
J Am Acad Orthop Surg. 2022 Jan 1;30(1):e99-e107. doi: 10.5435/JAAOS-D-21-00105.ABSTRACTAIMS: The purpose of this study is to determine differences in the rates of 90-day postoperative complications and 2- and 5-year surgical outcomes between patients with and without hereditary hemochromatosis (HH) after total joint arthroplasty (TJA).METHODS: Patients who underwent primary total hip arthroplasty (THA) or total knee arthroplasty (TKA) from 2010 to 2018 were identified in a national database (PearlDiver Technologies) using Current Procedural Terminology and International Classification of Diseases-9/10 codes. Patients with...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Authors: Source Type: research
Bosn J Basic Med Sci. 2021 Dec 19. doi: 10.17305/bjbms.2021.6538. Online ahead of print.ABSTRACTOsteoarthritis and rheumatoid arthritis are the most ubiquitous joint disorders which cause tremendous loss of life quality and impose an economic burden on society. At present, the treatment options for these two diseases comprise non-operative and surgical treatments, amongst those total knee arthroplasties (TKA). Various studies have recognized smoking as a significant risk factor for postoperative complications. Therefore, the purpose of this study was to examine the impact of smoking on the incidence and postoperative compl...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Authors: Source Type: research
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