The efficacy, safety, and cost-effectives of combined administration of Intravenous and Local Tranexamic Acid in the management of Patients Undergoing Primary Total Hip Arthroplasty: A prospective, blinded and randomized clinical study

CONCLUSION: Combined administration of IV and local tranexamic acid seems to be more effective in reducing the requirement and amount of blood transfusion without increasing the risk of thromboembolic complications in primary THA compared to IV or local administrations. Despite increasing the prophylaxis costs, combined administration of TXA can result in lower total hospitalization costs by decreasing blood loss and consequent treatment costs in primary THA.LEVEL OF EVIDENCE: Level I, Randomized Controlled Trial.PMID:34730529 | DOI:10.5152/j.aott.2021.20397
Source: Acta Orthopaedica et Traumatologica Turcica - Category: Orthopaedics Authors: Source Type: research