Topical Rosemary officinalis essential oil improves wound healing against disseminated Candida albicans infection in rat model

This study evaluated the effect of a topical application of Rosemary officinalis essential oil ointment on a wound infected with Candida albicans, in rats. Sixty-three mature Wistar rats were allocated into three equal groups (n = 21 each): control, 2 % rosemary cream-treated and 4 % rosemary cream-treated. The rats underwent general anaesthesia, and a wound area with dimensions of 1.5 × 1.5 cm was created between the shoulders. Then, 0.1 ml of a solution containing C. albicans yeast (1.5 × 107 colony forming unit (CFU)) was applied to the wound. The subsequent healing process was assessed by histology, microbial examination and assessment of the percentage wound contraction. Our data showed a significant difference between control and treated groups indicating that Rosemary officinalis’ anti-yeast properties accelerated the healing process in infected wounds and that the 4 % treatment showed significantly better results versus both control and 2 % treated groups.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research