NAMPT-derived NAD < sup > + < /sup > fuels PARP1 to promote skin inflammation through parthanatos cell death

In conclusion, hyperactivation of PARP1 in response to ROS-induced DNA damage, fueled by NAMPT-derived NAD+, mediates skin inflammation through parthanatos cell death.

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Source: PLoS Biology: Archived Table of Contents - November 8, 2021 Category: Biology Authors: Francisco J. Mart ínez-Morcillo Source Type: research