Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling

In conclusion, AO induced hepatotoxicity by activating NLRP3 inflammasome signaling, at least in part, through increased KCNN4 and ROS production, and NF-κB inhibition.PMID:34718095 | DOI:10.1016/j.toxlet.2021.10.011

Source: Toxicology Letters - October 31, 2021 Category: Toxicology Authors: Manjiang Hu Li Lin Jun Liu Yizhou Zhong Boxuan Liang Yuji Huang Zhiming Li Xi Lin Bo Wang Bingli Zhang Hao Meng Rongyi Ye Jiaxin Du Mingzhu Dai Yi Peng Hongqun Li Qinghong Wu Hongbin Gao Xingfen Yang Zhenlie Huang Source Type: research