The impact of age and genetics on naltrexone biotransformation - Stancil SL, Nolte W, Pearce RE, Staggs VSPD, Leeder JS.
Naltrexone (NTX), an opioid antagonist primarily metabolized by Aldo-Keto Reductase 1C4 (AKR1C4), treats pediatric conditions involving compulsiveness (e.g., autism spectrum, Prader-Willi, eating disorders, non-suicidal self-injury). Pharmacokinetic variab...
A five-year-old boy with autism is now thriving at school, despite the impact of lockdown.
ConclusionsRegardless of a patient ’s baseline symptom severity, CBT and ADM-c both prevent depressive relapse substantially better than medication discontinuation. Given the shorter duration of treatment and equivalent longer-term outcomes, treatment with CBT might be considered a first choice for adults with depression.
The objective of this study is to evaluate the life course effects of racism on depressive symptoms in young Black women and to identify particularly sensitive periods. Guided by life-course theory and using logistic regression, we analyzed baseline data on racism frequency and stress from racism at two time periods (before age 20 and during the 20s) and follow-up data (at approximate 20-month intervals) on depressive symptoms (using a modified 11-item Center for Epidemiologic Studies Depression Scale, CES-D) among 1612 Black women participants aged 23 –34 years living in Detroit, MI. Of the 1612 women, 65% repo...
After one of his sons fell into a deep depression, he helped him recover. He later licensed an antidepressant that was a boon to his pharmaceutical company.
A team at the Medical University of South Carolina (MUSC) is working on testin...Read more on AuntMinnie.comRelated Reading: Whole-spine MRI uncovers abusive head trauma injuries in children What MRI sequence is best for brain volumetry? MRI scans show how autism affects young brains over time Portable MRI developer Hyperfine sets sights on Europe MRI shows how head impacts affect brains of young football players
Condition: Autism Spectrum Disorder Interventions: Behavioral: Overheard Speech; Behavioral: Addressed Speech Sponsors: New York University; Emerson College Recruiting
Condition: Autism Interventions: Other: visual motor integration group; Other: Handwriting intervention programs; Other: visual motor integration program and Handwriting intervention programs Sponsor: Misr University for Science and Technology Enrolling by invitation
Conditions: Opioid Use Disorder, Severe, in Sustained Remission; Opioid Use Disorder, Severe, in Early Remission; Major Depressive Disorder Intervention: Drug: Ketamine-assisted psychotherapy Sponsor: Medical University of South Carolina Recruiting
Mental health, meet venture capital (APA): Until recently, mental health was a relative blip on the radar of venture capitalists. But over the past few years, and particularly since the onset of the COVID-19 pandemic, private investors have made a dramatic run for this space, pouring $3.1 billion into mental health ventures by the third quarter of 2021 alone, according to Rock Health, a seed fund that supports startups working in digital health. That represents a third of all digital health funding for 2021, more than 7 times the amount of funding placed in such ventures in 2015. The reasons for this boom are clear. The pa...
Conclusion: Patients with SCZ had poorer cognitive function, which is related to their hippocampal pathology, than those with mood disorders.Neuropsychobiology