Impact of cholesterol on proinflammatory monocyte production by the bone marrow

ConclusionsCollectively, these data highlight that LDL-C impacts haematopoiesis, promoting both the number and the proinflammatory activation of circulating monocytes. Furthermore, this study reveals a potential contributory role of HSPC transcriptomic reprogramming to residual inflammatory risk in FH patients despite cholesterol-lowering therapy.
Source: European Heart Journal - Category: Cardiology Source Type: research