Pan-cancer Analysis of Homologous Recombination Repair-associated Gene Alterations and Genome-wide Loss of Heterozygosity Score

CONCLUSION: Biallelic alterations in core HRR-associated genes are frequent, strongly associated with elevated gLOH, and enriched in breast, ovarian, pancreatic, and prostate cancer. This analysis could inform the design of the next generation of clinical trials examining DNA repair-targeting agents, including poly-ADP ribose polymerase inhibitors.PMID:34740923 | DOI:10.1158/1078-0432.CCR-21-2096

Source: Clinical Breast Cancer - November 6, 2021 Category: Cancer & Oncology Authors: Benedikt Westphalen Alexander D Fine Fabrice Andre Shridar Ganesan Volker Heinemann Etienne Rouleau Clare Turnbull Luis Garcia Palacios Jorge Antonio Lopez Ethan S Sokol Joaquin Mateo Source Type: research