Impact of natriuretic peptide polymorphisms on diastolic and metabolic function in a populational cohort: insights from the STANISLAS cohort

ConclusionsThe heritability of natriuretic peptides appears relatively low (15%) and mainly based on the same gene cluster constituted ofMTHFR,CLCN6,NPPA,NPPB, andC1orf167. Natriuretic peptide polymorphisms are associated with natriuretic peptide levels and diastolic function. These results suggest that natriuretic peptide polymorphisms may have an impact in the early stages of cardiovascular and metabolic disease.

Source: ESC Heart Failure - November 4, 2021 Category: Cardiology Authors: Constance Xhaard, Rapha ël Rouget, Nicolas Vodovar, Edith Le Floch, Claire Dandine‐Roulland, Sandra Wagner, Delphine Bacq‐Daian, Quentin Thuillier, Jean‐Marc Boivin, Christiane Branlant, Jean‐François Deleuze, Isabelle Behm‐Ansmant, Tags: Original Article Source Type: research