Hexokinases II ‐mediated glycolysis governs susceptibility to crizotinib in ALK‐positive non‐small cell lung cancer

ConclusionsThese results indicate that HK2-mediated glycolysis plays a crucial role in the increased tolerance of ALK+ NSCLC cells to crizotinib. 2DG may sensitize ALK+ NSCLC to crizotinib via suppression of HK2-mediated glycolysis and the AKT/mTOR signaling pathway.

Source: Thoracic Cancer - November 3, 2021 Category: Cancer & Oncology Authors: Caiyu Lin, Hengyi Chen, Rui Han, Li Li, Conghua Lu, Shuai Hao, Yubo Wang, Yong He Tags: ORIGINAL ARTICLE Source Type: research