Complications of Lipodystrophy Syndromes

Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis or may develop over time as the disease progresses. In addition to metabolic abnormalities, subtype-specific presentations due to underlying molecular etiology in genetic forms and autoimmunity in acquired forms contribute to severe morbidity in lipodystrophy.PMID:34728268 | DOI:10.1016/j.lpm.2021.104085
Source: Presse Medicale - Category: General Medicine Authors: Source Type: research