Virtual Chromoendoscopy With Magnification in Coeliac Disease.

Condition:   Celiac Disease Interventions:   Diagnostic Test: High-definition white light endoscopy (HD-WLE);   Diagnostic Test: HD-WLE plus I-Scan optical enhancement (OE) virtual chromoendoscopy with High-definition optical magnification (HD-OM) Sponsor:   Instituto Ecuatoriano de Enfermedades Digestivas Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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CONCLUSION: Gastric and duodenal biopsy specimens seem to have limited diagnostic value for the exclusion of generalized or eosinophilic GI disorders in adults with EoE.KEY POINTSEvidence is lacking on the diagnostic value of additional biopsies sampled form the stomach and duodenum to rule out other relevant generalized or eosinophilic gastrointestinal (GI) disorders.The yield of gastric and duodenal biopsies routinely sampled in our cohort was 3.6% for a relevant other generalized or eosinophilic GI diagnosis and 30% for other histological diagnosis such as non-specific or H. Pylori gastritis.The diagnostic yield for a r...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Authors: Potter MD, Hunt JS, Walker MM, Jones M, Liu C, Weltman M, Talley NJ Abstract Introduction: Duodenal eosinophilia is a key feature of functional dyspepsia, particularly in those with early satiety. Duodenal eosinophilia is also recognised in coeliac disease, although its relevance to symptoms is not understood. We aimed to determine if duodenal eosinophilia is present in patients with coeliac disease presenting with dyspepsia, and whether other histological characteristics were associated with clinical features on presentation.Methods: The coeliac study population comprised 61 patients with a new presentati...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
A 56 year-old-men, with history of celiac disease (CD), was referred to our endoscopy unit based on the suspicion of a submucosal gastric tumor. During the esophagogastroduodenoscopy (EGD) a submucosal lesion of about 3  cm was observed at the level of the great curvature of the gastric antrum. A computed tomography (CT) scan showed a 32 mm diameter cyst inside the gastric wall, with wall contrast-enhancement, suspected for parasitic cyst. An endoscopic ultrasonography (EUS) was performed with a linear scope (G F-UCT 180 - Olympus, Hamburg) showing, inside the gastric muscular layer, the presence of a submucosal lesion...
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
Gluten? Lactose? Stomach pain? Digestive troubles? Way too many people suffer from gastrointestinal issues, and much less are aware of the digital technologies that can come to their aid. Did you know that digestibles could successfully replace the dreaded colonoscopy? Or have you heard about microbiome testing? What about the swarm of health apps supporting dietary restrictions? We took a deep breath and jumped into the universe of digital technologies just to bring you as much information about the future of gastroenterology as possible. Will you jump after us? IBS, colorectal cancer, and other animals Referring to...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Genomics Health Sensors & Trackers diet dieting digestibles digestion digital health gastro gastroenterologist gastroenterology gastrointestinal gluten gut Innovation lactose microbiome stomach techno Source Type: blogs
Endosc Int OpenDOI: 10.1055/s-0042-105955 Background and aims: Severe villous atrophy can be revealed with conventional white light endoscopy (WLE), however, milder grades or patchy villous atrophy are more difficult to detect. Novel endoscopic techniques such as high definition i-SCAN endoscopy with the water immersion technique (i-SCAN-HDWI) may provide the ability to visualize duodenal villi more accurately. We aimed to determine the performance of i-SCAN-HDWI in evaluating the severity of histological damage in the duodenum of patients with celiac disease. Patients and methods: A retrospective cohort study wa...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Celiac disease remains underdiagnosed at endoscopy. We aimed to assess the utility of I-Scan (virtual chromo-endoscopy) to improve sensitivity of endoscopy to detect markers of villous atrophy in this condition.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Alimentary Tract Source Type: research
Authors: Donnelly SC, Šuligoj T, Ellis HJ, Ciclitira PJ Abstract Objective Coeliac disease affects approximately 1% of Northern American and European populations. It is caused by an inappropriate immune response to dietary gluten. Gluten comprises of two major protein fractions: gliadins and glutenins. Glutenins have recently been found to be toxic to coeliac individuals. Proliferation assays suggest in some but not all paediatric coeliac individuals there may be immunological stimulation with high molecular weight (HMW) glutenins. Less evidence pertains to low molecular weight (LMW) glutenins. The aim is to...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Question: A 65-year old woman presents for evaluation of chronic postprandial abdominal pain and nausea. She first developed symptoms 3 years earlier with an associated 40-lb weight loss. Initial workup included upper and lower endoscopy, celiac serologies, computed tomography (CT) scan, and MR enterography, all unremarkable. She was trialed on acid suppressive therapy, antispasmodics, and antiemetics with little benefit, although nonabsorbable oral antibiotics did improve symptoms. After presenting with an acute exacerbation of symptoms, a CT scan showed focal pneumatosis of distal small bowel and pneumoperitoneum.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Electronic Clinical Challenges and Images in GI Source Type: research
Many of you know that the Wheat Belly concepts got their start when I was trying to help patients in my cardiology practice obtain better control over risk for coronary disease. An exceptionally common combination of abnormalities in people with heart attacks, survivors of sudden cardiac death, those who have undergone stent implantation or bypass surgery, or have high coronary calcium scores (an early quantifier of coronary atherosclerotic plaque): large quantities of small LDL particles and high blood sugars (high fasting glucose and/or hemoglobin A1c, HbA1c, reflecting long-term blood sugar fluctuations). Because wheat...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories cholesterol gluten grains lipids lipoproteins ulcerative colitis Weight Loss Source Type: blogs
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