Severe acute asthma at the Paediatric Intensive Care Unit: can we link the clinical phenotypes to immunological endotypes?

Expert Rev Respir Med. 2021 Oct 28. doi: 10.1080/17476348.2021.1997597. Online ahead of print.ABSTRACTINTRODUCTION: The clinical phenotype of severe acute asthma at the Paediatric Intensive Care Unit (PICU) is highly heterogeneous. However, current treatment is still based on a 'one size fits all approach'.AREAS COVERED: We aim to give a comprehensive description of the clinical characteristics of paediatric patients with severe acute asthma admitted to the PICU and available immunological biomarkers, providing the first steps towards precision medicine for this patient population. A literature search was performed using PubMed for relevant studies on severe acute (pediatric) asthma.EXPERT OPINION: Omics technologies should be used to investigate the relationship between cellular molecules and pathways, and their clinical phenotypes. Inflammatory phenotypes might guide bedside decisions regarding the use of corticosteroids, neutrophil modifiers and/or type of beta-agonist. A next step towards precision medicine should be inclusion of these patients in clinical trials on biologicals.PMID:34709100 | DOI:10.1080/17476348.2021.1997597
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research