Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation

In conclusion, VAP-1 expression allows the characterization and prospective isolation of a new subset of human HSC. Since VAP-1 serves as a check point-like inhibitor in HSC differentiation, the use of VAP-1 inhibitors enables the expansion of HSC.PMID:34719737 | DOI:10.1007/s00018-021-03977-6

Source: Cellular and Molecular Life Sciences : CMLS - November 1, 2021 Category: Cytology Authors: Imtiaz Iftakhar-E-Khuda Alberto Pessia Shuyu Zheng Matti Kankainen Mika Kontro Marika Karikoski Juha Laurila Heidi Gerke Sina Tadayon Maija Hollm én Jing Tang Beat A Imhof Marko Salmi Sirpa Jalkanen Source Type: research