A BioBricks ® toolbox for metabolic engineering of the tetracenomycin pathway

CONCLUSIONS AND IMPLICATIONS: Altogether, this system is compatible with the BioBricks® [RFC 10] cloning standard for the co-expression of multiple gene sets for metabolic engineering of Streptomyces coelicolor M1146::cos16F4iE. This production platform improves access to potent analogs, such as tetracenomycin X, and sets the stage for the production of new tetracenomycins via combinatorial biosynthesis. This article is protected by copyright. All rights reserved.PMID:34719127 | DOI:10.1002/biot.202100371
Source: Biotechnology Journal - Category: Biotechnology Authors: Source Type: research
More News: Biotechnology | Genetics