Participant(s) With Autism and High Pain Tolerance Treated With High Dose Naltrexone

Condition:   Autism Spectrum Disorder Intervention:   Drug: 50 mg naltrexone Sponsor:   State University of New York - Upstate Medical University Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This study identifies salivary micro-transcriptome features with differential expression among children with ASD-related GI disturbance. A subset of the RNAs displays relationships with treatment modality and are associated with autistic behaviors. The pathobiologic targets of the micro-transcriptome markers may serve as targets for individualized therapeutic interventions aimed at easing pain and behavioral difficulties seen in ASD-related GI disturbance.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Case Rep Psychiatry. 2021 Dec 14;2021:7334467. doi: 10.1155/2021/7334467. eCollection 2021.ABSTRACTWe are presenting the case of a 38-year-old woman with nonverbal autism and intellectual disability, hospitalized in a neurobehavioural unit because of a pica behaviour for 3 years. During the hospitalization, the patient presented an episode of pain, agitation, restlessness, rhabdomyolysis, coma, tachycardia, hyperthermia, shivering, and diarrhoea. The main hypothesis raised was tramadol overdose because of the immediate antidote response to the injection of naloxone 0,4 mg/mL. Even if we did not exceed the recommended presc...
Source: Case Reports in Psychiatry - Category: Psychiatry Authors: Source Type: research
J Family Med Prim Care. 2021 Oct;10(10):3845-3850. doi: 10.4103/jfmpc.jfmpc_439_21. Epub 2021 Nov 5.ABSTRACTBACKGROUND: Autism is reportedly the most severe neuropsychiatric disorder affecting children. Autistic subjects can be characterized by impairments in social interactive behavior along with restricted interests and quite frequently, are seen exhibiting repetitive behavior patterns in stereotyped manner. The inability to perform routine tasks can widely impact the oral health and also, the constant care and sense of helplessness might drastically affect quality of life.AIM: The aim of the study was to assess the oral...
Source: Primary Care - Category: Primary Care Authors: Source Type: research
The call came, as always, when I least expected it. Of course it does, because if I had been expecting it I would have called him first. But there I was, blithely going about my business, doing my work, as if I were like anyone else. But, you see, I’m not. I am an autism mom and that means I need to be life-or-death alert like a rabbit, on call like an ER surgeon.  My beautiful bright son Nat is now 32 and so capable, so competent, mature, and dependable. But he is strung so delicately, like a fine old Stradivarius, and his music is just as beautiful, but it doesn’t take much to knock him out of tune. I lo...
Source: Susan's Blog - Category: Child Development Authors: Tags: Uncategorized Source Type: blogs
Source: Pediatrics in Review - Category: Pediatrics Source Type: research
A 12-year-old boy was admitted to the paediatric ward with a 4-month history of worsening pain and bruising to his legs, which had resulted in a progressive reduction in his mobility. He initially had had difficulty weight bearing, which had then progressed further making him wheelchair bound. On examination, there was extensive bruising (figure 1) to his oedematous legs, worse on his right leg compared with his left. His background of autism and 15q13.3 deletion, along with maternal learning difficulties, made deciphering a clear history difficult. However, there was no account of trauma, and he had been afebrile througho...
Source: Archives of Disease in Childhood - Education and Practice - Category: Pediatrics Authors: Tags: Epilogue Source Type: research
Neuropharmacology. 2021 Nov 10:108878. doi: 10.1016/j.neuropharm.2021.108878. Online ahead of print.ABSTRACTNeurobiology of social contagion/empathy aims to collaborate with the development of treatments for human disorders characterized by the absence of this response - autism spectrum disorder, schizophrenia, and antisocial personality disorder. Previous studies using sustained aversive stimuli (e.g., neuropathic pain or stress) to induce social contagion behaviors in rodents have demonstrated that these conditions may increase hypernociception, anxiogenic-like effects, and defensive behaviors in cagemates. To amplify th...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
ley Prior to COVID-19, research into teletherapy models for individuals on the autism spectrum was slowly progressing. Following the onset of COVID-19, teletherapy became a necessity for continuity of services, however, research was still emerging for how to translate best practice autism support to the online environment. The aim of this research was to gain insight into the rapid shift to teletherapy for practitioner and service users and the implications for the broader disability sector. Survey responses were collected from 141 allied health practitioners (speech pathologists, occupational therapists, psychologists...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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