Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1 α-VEGF pathway

In conclusion, our results indicate that rTMD1 not only has dual effects to suppress PA and inflammation in OIR, but also can be a potential HIF-1α inhibitor for clinical use. These data bring forth the possibility of rTMD1 as a novel therapeutic agent for PA.PMID:34705054 | DOI:10.1007/s00018-021-03950-3
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research