Clozapine dosing

I was just curious on how others are dosing clozapine. It has a pretty wide ranging half life, smoking can affect it, all kinds of other variables, etc. I know prescription recommendations are to dose bid, but I almost never do this. My own practice has been to start at bedtime and titrate upward only at bedtime. Rarely, if they are struggling with daytime psychosis I'll add a smaller dose in the mornings, but usually only 25 or 50 mg, with the bulk being at bedtime. When I've tried to... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums