Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia

Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

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Conclusions: BAL improves the effectiveness of MBT detection in children and adolescents with pulmonary TB without MTB positive sputum samples by 60 % (95%CI: 43.6 -74.5) Wilson's method) due to RMT. Depending on the age, the effectiveness ranges from 33.3% to 80%.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
The GeneLEAD VIII (Diagenode, Belgium) is a new, fully automated, sample-to-result precision instrument for the extraction of DNA and PCR detection of Mycobacterium tuberculosis complex (MTBC) directly from clinical samples. The Deeplex Myc-TB® assay (Genoscreen, France) is a diagnostic kit based on the deep sequencing of a 24-plexed amplicon mix allowing simultaneously the detection of resistance to 13 antituberculous (antiTB) drugs and the determination of spoligotype. We evaluated the performance of a strategy combining the both mentioned tools to detect directly from clinical samples, in 8 days, MTBC and its resist...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
CONCLUSION: MDR-LAMP is a rapid and accessible assay for the laboratory identification of rifampicin and isoniazid resistance of Mtb isolates.PMID:34474721 | DOI:10.3967/bes2021.085
Source: Biomedical and Environmental Sciences : BES - Category: Biomedical Science Authors: Source Type: research
CONCLUSIONS: Multicentric trial of TruenatTM MTB-RIF demonstrated a great potential of this point of care NAAT for detection of MDR-TB. The test would be useful in limited resource settings and inaccessible areas without need for any additional infrastructure.PMID:33707390 | DOI:10.4103/ijmr.IJMR_2557_19
Source: The Indian Journal of Medical Research - Category: Biomedical Science Authors: Source Type: research
More News: Ethiopia Health | Infectious Diseases | Multidrug Resistance | Papanicolaou (Pap) Smear | Tuberculosis