Recent progress on n-butanol production by lactic acid bacteria

Abstractn-Butanol is an essential chemical intermediate produced through microbial fermentation. However, its toxicity to microbial cells has limited its production to a great extent. The anaerobe lactic acid bacteria (LAB) are the most resistant ton-butanol, so it should be the first choice for improvingn-butanol production. The present article aims to review the following aspects ofn-butanol production by LAB: (1) the tolerance of LAB ton-butanol, including its tolerance level and potential tolerance mechanisms; (2) genome editing tools in then-butanol-resistant LAB; (3) methods of LAB modification forn-butanol production and the production levels after modification. This review will provide a theoretical basis for further research onn-butanol production by LAB.
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research