Correction to: Effectiveness of naloxegol in patients with cancer pain suffering from opioid ‑induced constipation

Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research

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Introduction: Implementation of patient-reported outcome measures (PROMs) may augment quality of care in lung cancer, but further data are needed to validate their exact clinical relevance in routine clinical practice.Aim: We herein aimed to investigate the effect of a PROMs tool on palliative care outcomes and overall quality of life (QoL) in patients with advanced-stage non-small cell lung cancer (NSCLC).Methods: 100 adult patients with stage IV NSCLC, diagnosed and treated at the Oncology Unit of "Sotiria" Athens General Hospital, were prospectively enrolled and randomized into two groups: the control group (r...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
The objectives of the review were to understand the health-related suffering in patients with breast cancer and to identify the scope of palliative care in improving the quality of life of patients with breast cancer.Recent FindingsBreast cancer causes suffering in physical, psychological, social, financial, and spiritual domains of the lives of the patient and family. Management of breast cancer with surgery, chemotherapy, and radiation could have adverse effects, such as pain, nausea and vomiting, fatigue, shortness of breath, depression, and constipation. Both cancer and its treatment can impact the psychosocial and spi...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
Enrico Ruggeri This observational study aims to evaluate the efficacy of naloxegol therapy in resolving opioid-induced constipation (OIC) and in improving the quality of life in a home palliative care cancer setting. Advanced cancer patients with OIC (Rome IV criteria) not relieved by laxatives started a naloxegol therapy 25 mg/day for 4 weeks. Quality of life was evaluated by Patient Assessment of Constipation Quality-of-Life (PAC-QoL) at day 0 and day 28; background pain by Numerical Rating Scale, number of weekly spontaneous bowel movements and Bowel Function Index (BFI) were evaluated at day 0 and every week. Se...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline dur...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Biol Pharm Bull. 2021;44(11):1746-1751. doi: 10.1248/bpb.b21-00474.ABSTRACTTramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor (MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in patients with cancer and non-cancer pain. However, the contribution of MOR to tramadol-induced constipation is unclear. Therefore, we used naldemedine, a peripherally acting MOR antagonist, and MOR-knockout mice to investigate the involvement of peripheral MOR in tramadol-induced constipation using a small intestinal transit model. A single dose of tramadol (3-100 mg/kg...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Source Type: research
ConclusionsPalliative care has received considerable socio-political support in recent years, due primarily to epidemiological developments. Depending on severity, life expectancy and the patients' personal circumstances, it can be delivered in a variety of settings, including private residences, assisted living facilities, acute and long-term care hospitals, hospice residences, correctional facilities, and homeless shelters. As a result, access barriers might be particularly complex to identify and overcome. Cross-country learning can be an important catalyst for future improvements.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
AbstractObjectiveGiven the rarity of refractory pheochromocytoma and paraganglioma (PPGL), outcomes and prognostic factors after131I-metaiodobenzylguanidine (131I-mIBG) treatment still remain unclear. Therefore, this study evaluated whether baseline characteristics at initial131I-mIBG therapy and imaging response to repeated131I-mIBG therapy could be prognostic factors for refractory PPGL.MethodsAll patients [n = 59 (male/female = 35/24), median age; 49.3 years] with refractory PPGL who received131I-mIBG therapy at our institution between September 2009 and September 2019 were retrospective...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
CONCLUSIONS: In this Phase I study, DMUC4064A demonstrated a tolerable safety profile along with encouraging efficacy in the indication of platinum-resistant OC.PMID:34627611 | DOI:10.1016/j.ygyno.2021.09.023
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: DIC is a frequent comorbidity of pain management and affects around one third of patients with NMP. It interferes significantly with pain-related biopsychosocial effects and has to be addressed specifically to improve the overall burden in affected patients. However, use of laxatives was significantly less frequent than recommended indicating significant room for improvement.PMID:34617483 | DOI:10.1080/03007995.2021.1990032
Source: Current Medical Research and Opinion - Category: Research Authors: Source Type: research
This study aimed to compare patient-reported outcomes between U-VATS and M-VATS for lung cancer lobectomy in the early postoperative period.METHODS: This comparative analysis used data from a longitudinal prospective study (CN-PRO-Lung 1). Symptom severity, functional status, and quality of life were compared between groups using generalized estimation equation models. Symptom severity and functional status were reported as proportion of patients with clinically meaningful severe scores on 0-10-point scales assessed using the MD Anderson Symptom Inventory-Lung Cancer module.RESULTS: Of the 174 patients included, 102 (58.6%...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
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