Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration

CONCLUSION: Faster and larger thrombus formation is induced in a dose-dependent manner by a wide range of FeCl3 concentrations, but the stable thrombus formation requires higher FeCl3 concentrations. Mouse strain affects thrombus formation and stability. RBCs and their interaction with platelets play a key role in the acceleration of FeCl3-induced thrombosis.PMID:34672137 | DOI:10.3349/ymj.2021.62.11.1032

Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yeseul Shim Il Kwon Youngseon Park Heow Won Lee Jayoung Kim Young Dae Kim Hyo Suk Nam Sungha Park Ji Hoe Heo Source Type: research